Letrozole Impurity D

Letrozole Impurity D - Names and Identifiers

Name	4,4'-(1-methylene) bis-Benzonitrile
Synonyms	4,4'-(1-Methylene) Letrozole Impurity D 4,4'-Dicyanodiphenylmethane 4,4'-methanediyldibenzonitrile Benzonitrile,4,4'-methylenebis- 4,4'-(1-METHYLENE) BIS-BENZONITRILE 4,4'-(1-methylene) bis-Benzonitrile 4-[(4-Cyanophenyl)methyl]benzonitrile
CAS	10466-37-2
InChI	InChI=1/C15H10N2/c16-10-14-5-1-12(2-6-14)9-13-3-7-15(11-17)8-4-13/h1-8H,9H2

Letrozole Impurity D - Physico-chemical Properties

Molecular Formula	C15H10N2
Molar Mass	218.25
Density	1.17±0.1 g/cm3(Predicted)
Melting Point	167 °C
Boling Point	410.6±38.0 °C(Predicted)
Flash Point	199.6°C
Solubility	Chloroform (Slightly)
Vapor Presure	5.96E-07mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Storage Condition	Room Temperature, under inert atmosphere
Refractive Index	1.617

Letrozole Impurity D - Introduction

4,4 '-Dicyanodiphenylmethane is an organic compound with the chemical formula C16H10N2. Here are some information about its nature, use, formulation and safety:

Nature:
- 4,4 '-Dicyanodiphenylmethane is a colorless crystal that is soluble in organic solvents, such as alcohols and ethers, and insoluble in water.
-It has a higher melting point and boiling point, 202-204°C and 450°C, so it is a stable compound.
-In the chemical reaction, it can break the covalent bond through the nuclear replacement reaction.

Use:
- 4,4 '-dicyanodiphenylmethane is mainly used as an important intermediate for polymer materials.
-It can be used to synthesize various polyamides, polyamic acids, polyimines, polyimides and other polymer compounds.
-These polymer materials are widely used in fibers, coatings, plastics, catalysts, polymer additives and other fields.

Preparation Method:
- 4,4 '-dicyanodiphenylmethane can be prepared by reacting terephthalic acid diester with sodium cyanide under alkaline conditions.
-First react the phthalic acid diester with sodium cyanide in an alkaline medium (such as ethanol) to produce two sodium salts of benzoic acid diester.
-Then, by heating, the two sodium salts of benzoic acid diesters are dealcoholized to form 4,4 '-dicyanodiphenylmethane.

Safety Information:
- 4,4 '-dicyanodiphenylmethane has low toxicity, but it is still necessary to pay attention to safe operation.
-When handling it, take appropriate protective measures, such as wearing gloves, goggles and protective clothing.
-Avoid contact with skin, eyes and respiratory tract to prevent possible irritation.
-When using or storing, keep away from fire and oxidant, and maintain a well-ventilated working environment.

Last Update：2024-04-10 22:29:15